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| CAS号 | 838818-26-1 | 货号 | BCP15357 |
| 中文名 | WIKI4 | ||
| 英文名 | WIKI4 | ||
| 中文别名 | |||
| 英文别名 | WIKI 4; WIKI-4; | ||
| SMILES | O=C1N(CCCSC2=NN=C(C3=CC=NC=C3)N2C4=CC=C(OC)C=C4)C(C5=CC=CC6=CC=CC1=C56)=O | ||
| 化学名称 | |||
| 分子式 | C29H23N5O3S | 分子量 | 521.59 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | WIKI4 is a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. WIKI4 inhibits expression of ß-catenin target genes and cellular responses to Wnt/ß-catenin signaling in cancer cell lines as well as in human embryonic stem cells. WIKI4 mediates its effects on Wnt/ß-catenin signaling by inhibiting the enzymatic activity of TNKS2, a regulator of AXIN ubiquitylation and degradation. While TNKS has previously been shown to be the target of small molecule inhibitors of Wnt/ß-catenin signaling, WIKI4 is structurally distinct from previously identified TNKS inhibitors. | ||
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Tags:WIKI4 供应商,WIKI4 购买,WIKI4 生产,WIKI4 批量,WIKI4 供应,WIKI4 订购,WIKI4 采购