ANA-12
| CAS号 | 219766-25-3 | 货号 | BCP16021 |
| 中文名 | ANA-12 | ||
| 英文名 | ANA-12 | ||
| 中文别名 | |||
| 英文别名 | ANA12;ANA 12; | ||
| 分子式 | C22H21N3O3S | 分子量 | 407.49 |
| 生物活性 | in vitro: ANA-12 prevented activation of the receptor by BDNF with a high potency. ANA-12 showed direct and selective binding to TrkB and inhibited processes downstream of TrkB without altering TrkA and TrkC functions. Saturation binding studies with TrkBECD-Fc showed that ANA-12 binds TrkBECD-Fc with a Kd of 12 μM [1]. The selective TrkB (tropomyosin-receptor-kinase) antagonist ANA-12 reduced OIH when given one or seven days after cessation of morphine. in vivo: Mice administered ANA-12 demonstrated reduced anxiety- and depression-related behaviors on a variety of tests predictive of anxiolytic and antidepressant properties in humans [1]. Administration of a BDNF receptor antagonist (the TrkB receptor antagonist ANA-12) reversed the diminished cocaine self-administration in male cocaine-sired rats. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | Trk Receptor | ||
结构式
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