Crenolanib besylate
| CAS号 | 670220-93-6 | 货号 | BCP24113 |
| 中文名 | Crenolanib besylate | ||
| 英文名 | Crenolanib besylate | ||
| 中文别名 | |||
| 英文别名 | Crenolanib besilate; CP 868596; CP868596; CP-868596; ARO 002; RO-002; RO002; | ||
| 分子式 | C32H35N5O5S | 分子量 | 601.72 |
| 生物活性 | Crenolanib Besylate is the besylate salt form of crenolanib, an orally bioavailable benzimidazole targeting the platelet-derived growth factor receptor (PDGFR) subtypes alpha and beta and FMS-related tyrosine kinase 3 (Flt3), with potential antineoplastic activity. Upon oral administration, crenolanib binds to and inhibits both wild-type and mutated forms of PDGFR and Flt3, which may result in the inhibition of PDGFR- and Flt3-related signal transduction pathways. This results in inhibition of tumor angiogenesis and tumor cell proliferation in PDGFR and/or Flt3 overexpressing tumor cells. PDGFR and Flt3, class III receptor tyrosine kinases, are upregulated or mutated in many tumor cell types. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | PDGFR | ||
结构式
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