Crenolanib besylate 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP24113CAS号：670220-93-6纯度：98%

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CAS号	670220-93-6	货号	BCP24113
中文名	Crenolanib besylate
英文名	Crenolanib besylate
中文别名
英文别名	Crenolanib besilate; CP 868596; CP868596; CP-868596; ARO 002; RO-002; RO002;
SMILES	CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4.C1=CC=C(C=C1)S(=O)(=O)O
化学名称
分子式	C32H35N5O5S	分子量	601.72
纯度	98%	配送	惯例下常温包邮
产品描述	Crenolanib Besylate is the besylate salt form of crenolanib, an orally bioavailable benzimidazole targeting the platelet-derived growth factor receptor (PDGFR) subtypes alpha and beta and FMS-related tyrosine kinase 3 (Flt3), with potential antineoplastic activity. Upon oral administration, crenolanib binds to and inhibits both wild-type and mutated forms of PDGFR and Flt3, which may result in the inhibition of PDGFR- and Flt3-related signal transduction pathways. This results in inhibition of tumor angiogenesis and tumor cell proliferation in PDGFR and/or Flt3 overexpressing tumor cells. PDGFR and Flt3, class III receptor tyrosine kinases, are upregulated or mutated in many tumor cell types.