GSA10
| CAS No. | 300833-95-8 | Cat. No. | BCP24130 |
| Name | GSA10 | ||
| Synonyms | GSA 10; GSA-10; | ||
| Formula | C26H30N2O4 | M. Wt | 434.54 |
| Description | GSA-10 is a Smoothened (Smo) receptor agonist (EC50 = 1.2 μM). GSA-10 fits to the agonist pharmacophoric model with two hydrogen bond acceptor groups and four hydrophobic regions. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 does not recognize the classic bodipy-cyclopamine binding site. GSA-10 allows the pharmacological characterization of a novel Smo active site, which is notably not targeted to the primary cilium and strongly potentiated by forskolin and cholera toxin. GSA-10 belongs to a new class of Smo agonists and will be helpful for dissecting Hh mechanism of action, with important implications in physiology and in therapy. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Smoothened/Smo | ||
Structure
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