PD 161570
| CAS号 | 192705-80-9 | 货号 | BCP24138 |
| 中文名 | PD 161570 | ||
| 英文名 | PD 161570 | ||
| 中文别名 | |||
| 英文别名 | PD 161570; PD161570; | ||
| 分子式 | C26H35Cl2N7O | 分子量 | 532.51 |
| 生物活性 | PD-161570 is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively). PD 161570 had about 5- and 100-fold greater selectivity toward the FGF-1 receptor (IC50 = 40 nM) compared with the PDGFbeta receptor (IC50 = 262 nM) or EGF receptor (IC50 = 3.7 microM) tyrosine kinases, respectively. In addition, PD 161570 suppressed constitutive phosphorylation of the FGF-1 receptor in both human ovarian carcinoma cells (A121(p)) and Sf9 insect cells overexpressing the human FGF-1 receptor and blocked the growth of A121(p) cells in culture. The results demonstrate a novel synthetic inhibitor with nanomolar potency and specificity towards the FGF-1 receptor tyrosine kinase. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway TGF beta/Smad | ||
| 靶 点 | BMP/TGF beta Receptor Src/Bcr Abl PDGFR EGFR | ||
结构式
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