HPI-4
| CAS No. | 302803-72-1 | Cat. No. | BCP18834 |
| Name | HPI-4 | ||
| Synonyms | CiliobrevinA;HPI 4;HPI4;Hedgehog Pathway Inhibitor 4; | ||
| Formula | C17H9Cl2N3O2 | M. Wt | 358.18 |
| Description | Ciliobrevin A, also known as HPI-4 and Hedgehog Pathway Inhibitor 4, is a Hedgehog pathway inhibitor. Treatment with HH pathway inhibitor-4 (HPI-4) could significantly decrease human chondrosarcoma cell proliferation, invasion and migration ability. Furthermore, HPI-4 could distinctly disturb HH pathway-mediated ciliogenesis and suppress primary cilia-related protein intraflagellar transport protein IFT88 expression. HH downstream effect molecular GLI2 was restrained to block parathyroid hormone-related protein and affect MAPK/ERK-regulated matrix metalloproteinases (MMP2 and MMP9). d HPI-4 could be a new therapeutic option specific to chondrosarcoma expressing elevated levels of HH pathway. | ||
| Pathways | Wnt/Stem Cell | ||
| Targets | Hedgehog | ||
Structure
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