Etelcalcetide
| CAS No. | 1262780-97-1 | Cat. No. | BCP25088 |
| Name | Etelcalcetide | ||
| Synonyms | AMG 416; KAI-4169;AMG416; KAI 4169;AMG-416; KAI4169; | ||
| Formula | C38H73N21O10S2 | M. Wt | 1048.25 |
| Description | Etelcalcetide is a calcimimetic and calcium-sensing receptor (CaSR) agonist composed of a synthetic peptide comprised of seven D-amino acids that can be used to treat secondary hyperparathyroidism (sHPT) in hemodialysis patients with chronic kidney disease (CKD). Upon intravenous administration, etelcalcetide mimics calcium and allosterically binds to and activates the CaSR expressed by the parathyroid gland. This suppresses the synthesis and secretion of parathyroid hormone (PTH), thereby reducing PTH levels and lowering serum calcium and phosphorus levels. Elevated PTH is often observed in patients with CKD and is associated with dysregulated calcium-phosphate homeostasis. | ||
| Pathways | GPCR/G Protein | ||
| Targets | CaSR | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.