Etelcalcetide HCl

  • Chemical Properties
CAS No. 1334237-71-6 Cat. No. BCP25093
Name Etelcalcetide HCl
Synonyms AMG 416; AMG-416; AMG416; KAI-4169; KAI4169; KAI 4169 HCl;
Formula C38H74ClN21O10S2 M. Wt 1084.72
  • Biological Activity
Description Etelcalcetide is a calcimimetic and calcium-sensing receptor (CaSR) agonist composed of a synthetic peptide comprised of seven D-amino acids that can be used to treat secondary hyperparathyroidism (sHPT) in hemodialysis patients with chronic kidney disease (CKD). Upon intravenous administration, etelcalcetide mimics calcium and allosterically binds to and activates the CaSR expressed by the parathyroid gland. This suppresses the synthesis and secretion of parathyroid hormone (PTH), thereby reducing PTH levels and lowering serum calcium and phosphorus levels. Elevated PTH is often observed in patients with CKD and is associated with dysregulated calcium-phosphate homeostasis.
Pathways GPCR/G Protein 
Targets CaSR 

Structure

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