Stigmatellin
| CAS No. | 91682-96-1 | Cat. No. | BCP25651 |
| Name | Stigmatellin | ||
| Synonyms | |||
| Formula | C30H42O7 | M. Wt | 514.65 |
| Description | Stigmatellin, a chromone inhibitor acting at the Q0 center of the bc1 complex, binds to the heme b-566 domain of cytochrome b as well as to the Fe2S2 protein. Its binding induces a shift of the alpha-band of heme b-566 to 568 nm. It does not influence the ligand field of the heme b-562 center. Concomitant with the red shift, stigmatellin gives rise to an alteration of the EPR line shape of the Fe2S2 cluster, namely linewidth narrowing and g value shifts at all 3 principal values. The midpoint redox potential of the Fe2S2 protein is shifted from 290 to 540 mV. | ||
| Pathways | Microbiology/Virology | ||
| Targets | Antibiotic | ||
Structure
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