COTI-2

Description	COTI-2 is an P53 gene modulator and AKT2 inhibitor. OTI-2 is active against multiple human cancer cell lines in vitro and in vivo. COTI-2 synergizes with therapeutic agents and does not induce resistance or exhibit cross-resistance in human cancer cell lines. COTI-2 is currnelty in clinical trials. Importantly, no overt toxicity was observed in the combination treatment groups in vivo. Furthermore, unlike the tested chemotherapeutic drugs, cancer cells did not develop resistance to COTI-2. Finally, some chemo-resistant tumor cell lines only showed mild cross-resistance to COTI-2 while most remained sensitive to it.
Pathways	Apoptosis Pathway
Targets	p53

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