(+)-ITD-1
| CAS No. | 1409968-46-2 | Cat. No. | BCP29917 |
| Name | (+)-ITD-1 | ||
| Synonyms | ITD-1, (+)-; | ||
| Formula | C27H29NO3 | M. Wt | 415.52 |
| Description | (+)-ITD-1 is the (+)-enantiomer of ITD 1 that is more active. ITD-1 is a selective inhibitor of TGFβ/Smad signaling (IC50 values 0.46 μM and 6.90 μM for (+)-ITD 1 and (−)-ITD 1, respectively for TGF-β inhibition) that clears the type II TGFβ receptor from the cell surface. ITD 1 promotes the differentiation of cardiomyocytes and cardiogenesis in murine embryonic stem cell (mESCs). | ||
| Pathways | TGF beta/Smad | ||
| Targets | TGF β/Smad | ||
Structure
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