(+)-ITD-1
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1409968-46-2 | Cat. No. | BCP29917 |
| Name | (+)-ITD-1 | ||
| Synonyms | ITD-1, (+)-; | ||
| SMILES | CCOC(=O)C1=C(NC2=C(C1C3=CC=C(C=C3)C4=CC=CC=C4)C(=O)CC(C2)(C)C)C | ||
| Chemical Name | |||
| Formula | C27H29NO3 | M. Wt | 415.52 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | (+)-ITD-1 is the (+)-enantiomer of ITD 1 that is more active. ITD-1 is a selective inhibitor of TGFβ/Smad signaling (IC50 values 0.46 μM and 6.90 μM for (+)-ITD 1 and (−)-ITD 1, respectively for TGF-β inhibition) that clears the type II TGFβ receptor from the cell surface. ITD 1 promotes the differentiation of cardiomyocytes and cardiogenesis in murine embryonic stem cell (mESCs). | ||
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