SIS3 New
Data Sheet
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| CAS No. | 1009104-85-1 | Cat. No. | BCP45559 |
| Name | SIS3 | ||
| Synonyms | SIS-3;SIS 3;Smad3 Inhibitor, SIS3; | ||
| SMILES | CN1C(=C(C2=C1N=CC=C2)C=CC(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5 | ||
| Chemical Name | |||
| Formula | C28H27N3O3 | M. Wt | 453.53 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SIS3 is an inhibitor of SMAD3, which is a receptor-regulated intracellular protein that functions downstream of TGF-β as well as activin receptors and mediates their signaling. It plays an important role in cell proliferation, apoptosis, differentiation and formation of extracellular matrix. It is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts. | ||
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