Halofuginone Hydrobromide New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 64924-67-0 | Cat. No. | BCP19376 |
| Name | Halofuginone Hydrobromide | ||
| Synonyms | Halofuginone HBr; Halofuginone-HBr; HalofuginoneHBr; | ||
| SMILES | C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Cl)Br)O.Br | ||
| Chemical Name | |||
| Formula | C16H18Br2ClN3O3 | M. Wt | 495.59 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases. | ||
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