SM16
| CAS No. | 614749-78-9 | Cat. No. | BCP30149 |
| Name | SM16 | ||
| Synonyms | SM-16; SM 16; | ||
| Formula | C25H26N4O3 | M. Wt | 430.51 |
| Description | SM16 was shown to bind with high affinity to ALK5 kinase ATP binding site using a competitive binding assay and biacore analysis. SM16 blocked TGF-beta and activin-induced Smad2/3 phosphorylation and TGF-beta-induced plasminogen activator inhibitor (PAI)-luciferase activity in cells. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase TGF beta/Smad | ||
| Targets | TGF β/Smad ALK | ||
Structure
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