BRD32048
| CAS号 | 433694-46-3 | 货号 | BCP30330 |
| 中文名 | BRD32048 | ||
| 英文名 | BRD32048 | ||
| 中文别名 | |||
| 英文别名 | BRD-32048; BRD 32048; | ||
| 分子式 | C16H22N6O | 分子量 | 314.39 |
| 生物活性 | BRD32048 is an inhibitor of the ETV1 transcription factor oncoprotein.ETS variant 1 (ETV1) is a transcription factor oncogene implicated in several cancers where it has been altered by chromosomal translocation, gene amplification, or lineage dysregulation.The ETV1 transcription factor is phosphorylated downstream of MAPK signaling and is acetylated at lysines 33 and 116 by the histone acetyltransferase p300.Both of these events increase the protein half-life of ETV1 and enhance its transcriptional activity. BRD32048 is a substituted [1,3,5]triazine derivative that inhibits ETV1 transcriptional activity by binding to ETV1 (KD = 17.1 µM in vitro), which reduces p300-dependent acetylation and stability of ETV1 and, thereby, promotes its degradation.2 At 20-100 µM, BRD32048 can dose-dependently prevent invasion of ETV1-reliant cancer cells in in vitro models. | ||
| 信号通路 | MAPK Pathway | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！