BRD32048 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP30330CAS号：433694-46-3纯度：98%

在线咨询

购买咨询

全国免运费！免费咨询：400-099-8200 或手机联系：13472751340

* 必填项

请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。

* Required Fields.

Please complete the form below and we will contact you shortly.

* Required Fields.

Please complete the form below and we will contact you shortly.

CAS号	433694-46-3	货号	BCP30330
中文名	BRD32048
英文名	BRD32048
中文别名
英文别名	BRD-32048; BRD 32048;
SMILES	COC1=CC=C(C=C1)NC2=NC(=NC(=N2)N)CN3CCCCC3
化学名称
分子式	C16H22N6O	分子量	314.39
纯度	98%	配送	惯例下常温包邮
产品描述	BRD32048 is an inhibitor of the ETV1 transcription factor oncoprotein.ETS variant 1 (ETV1) is a transcription factor oncogene implicated in several cancers where it has been altered by chromosomal translocation, gene amplification, or lineage dysregulation.The ETV1 transcription factor is phosphorylated downstream of MAPK signaling and is acetylated at lysines 33 and 116 by the histone acetyltransferase p300.Both of these events increase the protein half-life of ETV1 and enhance its transcriptional activity. BRD32048 is a substituted [1,3,5]triazine derivative that inhibits ETV1 transcriptional activity by binding to ETV1 (KD = 17.1 µM in vitro), which reduces p300-dependent acetylation and stability of ETV1 and, thereby, promotes its degradation.2 At 20-100 µM, BRD32048 can dose-dependently prevent invasion of ETV1-reliant cancer cells in in vitro models.