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| CAS号 | 1640282-42-3 | 货号 | BCP43532 |
| 中文名 | Zunsemetinib | ||
| 英文名 | Zunsemetinib | ||
| 中文别名 | |||
| 英文别名 | ATI-450; ATI450; ATI 450; CDD-450; CDD 450; CDD450; | ||
| SMILES | CC1=CC(=C(C(=O)N1C2=CC(=NC=C2C)C3=NC(=NC=C3)C(C)(C)O)Cl)OCC4=C(C=C(C=N4)F)F | ||
| 化学名称 | |||
| 分子式 | C25H22ClF2N5O3 | 分子量 | 513.93 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Zunsemetinib is an orally bioavailable, small molecule inhibitor of mitogen-activated protein (MAP) kinase-activated protein kinase 2 (MAPKAPK2; MK2), with potential anti-inflammatory activity. Upon oral administration, zunsemetinib targets and binds to the p38MAPK-MK2 complex, thereby inhibiting the p38MAPK phosphorylation and activation of MK2. This inhibits p38MAPK/MK2-mediated inflammatory signaling pathway. This may result in the inhibition of the production of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1-alpha, IL-1-beta and IL-6. | ||
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