Zunsemetinib

化学数据

CAS号	1640282-42-3	货号	BCP43532
中文名	Zunsemetinib
英文名	Zunsemetinib
中文别名
英文别名	ATI-450; ATI450; ATI 450; CDD-450; CDD 450; CDD450;
分子式	C25H22ClF2N5O3	分子量	513.93

用途

生物活性	Zunsemetinib is an orally bioavailable, small molecule inhibitor of mitogen-activated protein (MAP) kinase-activated protein kinase 2 (MAPKAPK2; MK2), with potential anti-inflammatory activity. Upon oral administration, zunsemetinib targets and binds to the p38MAPK-MK2 complex, thereby inhibiting the p38MAPK phosphorylation and activation of MK2. This inhibits p38MAPK/MK2-mediated inflammatory signaling pathway. This may result in the inhibition of the production of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1-alpha, IL-1-beta and IL-6.
信号通路	MAPK Pathway

结构式

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