优立替尼盐酸盐
| CAS号 | 1956366-10-1 | 货号 | BCP30834 |
| 中文名 | 优立替尼盐酸盐 | ||
| 英文名 | Ulixertinib hydrochloride | ||
| 中文别名 | 盐酸优立替尼; | ||
| 英文别名 | Ulixertinib HCl;BVD-523 HCl;BVD 523 HCl;BVD523 HCl;VRT752271 HCl;VRT752271 HCl; VRT 752271 HCl;Ulixertinib HCl salt; | ||
| 分子式 | C21H23Cl3N4O2 | 分子量 | 469.79 |
| 生物活性 | Ulixertinib, also known as BVD-523 and VRT752271, is an inhibitors of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. | ||
| 信号通路 | MAPK Pathway | ||
| 靶 点 | MEK/ERK | ||
结构式
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