MAZ51
| CAS No. | 163655-37-6 | Cat. No. | BCP31595 |
| Name | MAZ51 | ||
| Synonyms | MAZ-51;MAZ 51; | ||
| Formula | C21H18N2O | M. Wt | 314.38 |
| Description | MAZ51 is an indolinone that selectively antagonizes the activation of VEGFR3 by VEGFC (IC50 = 1 μM) without blocking VEGFC-mediated stimulation of VEGFR2.It does not inhibit ligand-induced autophosphorylation of EGFR, IGF-1R, or PDGFRβ.By preventing VEGFR3 activation, MAZ51 interferes with an autocrine loop involving the induced expression of the ligand VEGFC as well as VEGFA. It reduces proliferation and induces apoptosis in a variety of cancer cells in vitro and suppresses tumor growth in vivo. MAZ51 is used to study the role of VEGFR3 in endothelial and cancer cell function and survival. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | VEGFR | ||
Structure
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