PK11007
| CAS No. | 874146-69-7 | Cat. No. | BCP32609 |
| Name | PK11007 | ||
| Synonyms | PK-11007; PK 11007; | ||
| Formula | C15H11ClFN5O3S2 | M. Wt | 427.86 |
| Description | PK11007 is an anti-p53 drug. PK11007 preferentially decreases viability in p53-compromised cancer cell lines IC50 values for inhibition of proliferation in a panel of 17 breast cell lines by PK11007 ranged from 2.3 to 42.2 μM. PK11007 induced apoptosis in p53 mutant cell lines. PK11007 is a potential approach for treating p53-mutated breast cancer, including the subgroup with TN disease. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | p53 | ||
Structure
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