JK-P3

  • Chemical Properties
CAS No. 942655-44-9 Cat. No. BCP32785
Name JK-P3
Synonyms 3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide;
Formula C18H17N3O3 M. Wt 323.34
  • Biological Activity
Description JK-P3 is novel inhibitor of VEGFR-2. JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50 = 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation.
Pathways Angiogenesis/Protein Tyrosine Kinase 
Targets VEGFR 

Structure

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