JK-P3
CAS No. | 942655-44-9 | Cat. No. | BCP32785 |
Name | JK-P3 | ||
Synonyms | 3,4-Dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)-benzamide; | ||
Formula | C18H17N3O3 | M. Wt | 323.34 |
Description | JK-P3 is novel inhibitor of VEGFR-2. JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50 = 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube formation in HUVEC without effecting endothelial cell proliferation. | ||
Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
Targets | VEGFR |
Structure
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