RN-18
| CAS No. | 431980-38-0 | Cat. No. | BCP33989 |
| Name | RN-18 | ||
| Synonyms | RN 18; RN18; | ||
| Formula | C20H16N2O4S | M. Wt | 380.42 |
| Description | RN-18 is an HIV-1 Vif inhibitor. RN-18 antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G. RN-18 increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting general proteasome-mediated protein degradation. RN-18 enhances Vif degradation only in the presence of A3G, reduces viral infectivity by increasing A3G incorporation into virions and enhances cytidine deamination of the viral genome. | ||
| Pathways | Microbiology/Virology | ||
| Targets | HIV | ||
Structure
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