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RN-18 Chemical Structure

RN-18

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP33989CAS No. ：431980-38-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 431980-38-0 Cat. No. BCP33989
Name RN-18
Synonyms RN 18; RN18;
SMILES O=C(NC1=CC=CC=C1OC)C2=CC=CC=C2SC3=CC=C([N+]([O-])=O)C=C3
Chemical Name
Formula C20H16N2O4S M. Wt 380.42
Purity 98% Storage Store at 4-8°C
Description RN-18 is an HIV-1 Vif inhibitor. RN-18 antagonizes Vif function and inhibits HIV-1 replication only in the presence of A3G. RN-18 increases cellular A3G levels in a Vif-dependent manner and increases A3G incorporation into virions without inhibiting general proteasome-mediated protein degradation. RN-18 enhances Vif degradation only in the presence of A3G, reduces viral infectivity by increasing A3G incorporation into virions and enhances cytidine deamination of the viral genome.
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