NBI-74330
| CAS No. | 855527-92-3 | Cat. No. | BCP34091 |
| Name | NBI-74330 | ||
| Synonyms | NBI 74330; NBI74330; | ||
| Formula | C32H27F4N5O3 | M. Wt | 605.58 |
| Description | NBI-74330 is an antagonist of CXC chemokine receptor 3 (CXCR3) with IC50 values of 7nM to18nM. NBI-74330 attenuates atherosclerotic plaque formation in LDL receptor-deficient mice. Chemokine receptor CXCR3 promotes growth of glioma. CXCR3 antagonism exerts a direct anti-glioma effect and this receptor may be a potential therapeutic target for treating human GBM. | ||
| Pathways | GPCR/G Protein | ||
| Targets | CXCR | ||
Structure
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