DS-1206b
| CAS No. | 1855860-24-0 | Cat. No. | BCP40272 |
| Name | DS-1206b | ||
| Synonyms | DS-1205; DS 1205; DS1205; DS-1205b; DS 1205b; DS1205b; | ||
| Formula | C41H42FN5O7 | M. Wt | 735.81 |
| Description | DS-1206b is a selective and potent AXL kinase inhibitor with IC50 of 1.3 nM. DS-1205 potently inhibited the hGAS6-induced migration in vitro with EC50 of 2.7 nM. DS-1205b monotherapy exerted significant antitumor activity in an NIH3T3-AXL allograft model. In an HCC827 xenograft model, combination treatment with DS-1205b and osimertinib significantly delayed on the onset of tumor resistance compared to osimertinib alone in a manner proportional to DS-1205b does. DS-1205b also showed a similar resistance delay effect with erlotinib combination in the same xenograft model. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | TAM Receptor | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.