DS-1206b New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1855860-24-0 | Cat. No. | BCP40272 |
| Name | DS-1206b | ||
| Synonyms | DS-1205; DS 1205; DS1205; DS-1205b; DS 1205b; DS1205b; | ||
| SMILES | CC1=CN=C(C=C1)C2=CN(C=C(C2=O)C(=O)NC3=CC(=C(C=C3)C4=C(N=CC(=C4)C5=CC(=C(C=C5)OCC6COCCO6)OC)N)F)CC7CCOCC7 | ||
| Chemical Name | |||
| Formula | C41H42FN5O7 | M. Wt | 735.81 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | DS-1206b is a selective and potent AXL kinase inhibitor with IC50 of 1.3 nM. DS-1205 potently inhibited the hGAS6-induced migration in vitro with EC50 of 2.7 nM. DS-1205b monotherapy exerted significant antitumor activity in an NIH3T3-AXL allograft model. In an HCC827 xenograft model, combination treatment with DS-1205b and osimertinib significantly delayed on the onset of tumor resistance compared to osimertinib alone in a manner proportional to DS-1205b does. DS-1205b also showed a similar resistance delay effect with erlotinib combination in the same xenograft model. | ||
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