Brilacidin tetrahydrochloride

  • Chemical Properties
CAS No. 1224095-99-1 Cat. No. BCP43398
Name Brilacidin tetrahydrochloride
Synonyms PMX30063; PMX-30063; PMX 30063; Brilacidin;
Formula C40H54Cl4F6N14O6 M. Wt 1082.7
  • Biological Activity
Description Brilacidin, also known as PMX30063, is an arylamide foldamer designed to replicate the amphiphilic properties of antimicrobial peptides while solving the problems encountered by peptide-based antimicrobials. Brilacidin, a broad-spectrum antibiotic, has potent Gram positive activity and Gram negative coverage, and is highly effective in treating the 'superbug' methicillin-resistant Staphylococcus aureus (MRSA). Brilacidin has low cytotoxicity against mammalian cells selectively targeting bacteria, directly and rapidly disrupting their membranes, resulting in the bacteria's death. Due to this unique mechanism of action (mimicking the host's natural immune response, proven to be successful in fighting off infections over millions of years of evolution), bacterial antibiotic resistance is less likely to develop.
Related Products 1224095-98-0 (Brilacidin)
Pathways Microbiology/Virology 
Targets Antibiotic 

Structure

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