CLK-IN-T3
| CAS No. | 2109805-56-1 | Cat. No. | BCP43827 |
| Name | CLK-IN-T3 | ||
| Synonyms | CLK Inhibitor T3; T3-CLK; MDK-5561; MDK 5561; MDK5561; | ||
| Formula | C28H30N6O2 | M. Wt | 482.58 |
| Description | CLK-IN-T3 is a pan-CLK inhibitor, CLK-IN-T3 as well as the negative control T3-CLK-N have been developed in collaboration with Takeda 3 (5). CLK-IN-T3 is a potent inhibitor of CLK1, CLK2 and CLK3 with IC50 of 0.67/15/110 nM, respectively. T3-CLK is >30 fold selective against the closest off targets DYRK1A and DYRK1B with an IC50 of 260 nM and 230 nM, respectively in cellular assays. T3-CLK is non-toxic in cells and inhibits the phosphorylation of SRSF in HeLa cells in a time and dose dependent manner. (https://www.thesgc.org/chemical-probes/T3-CLK) | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | CDK | ||
Structure
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