Encorafenib

  • Chemical Properties
CAS No. 1269440-29-0 Cat. No. BCP44104
Name Encorafenib
Synonyms LGX818; LGX-818; LGX 818;
Formula C22H27ClFN7O4S M. Wt 540.01
  • Biological Activity
Description Encorafenib is an orally available Raf kinase inhibitor with potential antineoplastic activity. Encorafenib specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival.
Pathways MAPK Pathway 
Targets Raf 

Structure

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