HaloPROTAC-E

  • Chemical Properties
CAS No. 2365478-58-4 Cat. No. BCP44601
Name HaloPROTAC-E
Synonyms
Formula C39H56ClN5O8S M. Wt 790.41
  • Biological Activity
Description HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14) and no other proteins were significantly degraded.
Pathways Others Pathway 
Targets PROTAC 

Structure

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