NV5138 hydrochloride
| CAS号 | NV5138HCl | 货号 | BCP46023 |
| 中文名 | NV5138 hydrochloride | ||
| 英文名 | NV-5138 hydrochloride | ||
| 中文别名 | |||
| 英文别名 | NV-5138 hydrochloride;NV 5138 hydrochloride; | ||
| 分子式 | C7H14ClF2NO2 | 分子量 | 217.64 |
| 生物活性 | NV-5138 is an orally and centrally active small-molecule drug for the treatment of major depressive disorder (MDD). It directly and selectively activates the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway by binding to and modulating sestrin2, a leucine amino acid sensor and upstream regulatory pathway. The mTORC1 pathway is the same signaling pathway that the NMDA receptor antagonist ketamine activates in the medial prefrontal cortex (mPFC) to mediate its rapid-acting antidepressant effects. A single oral dose of NV-5138 has been found to increase mTORC1 signaling and produce synaptogenesis in the mPFC and to induce rapid antidepressant effects in multiple animal models of depression. | ||
| 上下游产品 | 2095886-80-7（NV-5138） | ||
| 信号通路 | PI3K/Akt/mTOR | ||
| 靶 点 | mTOR | ||
结构式
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