NV5138 hydrochloride 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP46023CAS号：NV5138HCl纯度：98%

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CAS号	NV5138HCl	货号	BCP46023
关联产品	2095886-80-7（NV-5138）
中文名	NV5138 hydrochloride
英文名	NV-5138 hydrochloride
中文别名
英文别名	NV-5138 hydrochloride;NV 5138 hydrochloride;
SMILES	CC(C)(CC(C(=O)O)N)C(F)F.Cl
化学名称
分子式	C7H14ClF2NO2	分子量	217.64
纯度	98%	配送	惯例下常温包邮
产品描述	NV-5138 is an orally and centrally active small-molecule drug for the treatment of major depressive disorder (MDD). It directly and selectively activates the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway by binding to and modulating sestrin2, a leucine amino acid sensor and upstream regulatory pathway. The mTORC1 pathway is the same signaling pathway that the NMDA receptor antagonist ketamine activates in the medial prefrontal cortex (mPFC) to mediate its rapid-acting antidepressant effects. A single oral dose of NV-5138 has been found to increase mTORC1 signaling and produce synaptogenesis in the mPFC and to induce rapid antidepressant effects in multiple animal models of depression.