Bisantrene dihydrochloride
| CAS No. | 71439-68-4 | Cat. No. | BCP46265 |
| Name | Bisantrene dihydrochloride | ||
| Synonyms | Bisantrene HCl;CL-216942; CL216942; CL 216942; | ||
| Formula | C22H24Cl2N8 | M. Wt | 471.39 |
| Description | Bisantrene is topoisomerase II poisons and DNA intercalators. It may be used as model compounds to study P-glycoprotein-mediated multiple drug resistance (MDR1). Bisantrene may be used as a Rac1 inhibitor. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. | ||
| Related Products | 78186-34-2（Bisantrene） | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Topoisomerase | ||
Structure
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