Box5
| CAS No. | 881188-48-3 | Cat. No. | BCP46893 |
| Name | Box5 | ||
| Synonyms | Box-5;Box 5; | ||
| Formula | C25H42N6O11S2 | M. Wt | 666.76 |
| Description | Box5 is a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist; abolishes exogenous Wnt5a stimulation of A2058 cells increased adhesion, migration and invasion, all crucial components of tumor metastasis, also inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling. | ||
| Pathways | Wnt/Stem Cell | ||
| Targets | Wnt | ||
Structure
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