NSC 146109 hydrochloride
| CAS No. | 59474-01-0 | Cat. No. | BCP48536 |
| Name | NSC 146109 hydrochloride | ||
| Synonyms | XI-011 hydrochloride;XI-011 HCl;XI-011; XI011; XI011; NSC 146109 HCl; NSC146109; NSC146109; | ||
| Formula | C17H17ClN2S | M. Wt | 316.85 |
| Description | NSC 146109, a small-molecule inhibitor of MDMX, showed robust anti-proliferation activity against several cervical cancer cell lines. XI-011 promoted apoptosis of cervical cancer cells via stabilizing p53 and activating its transcription activity. Moreover, XI-011 inhibited the growth of xenograft tumor in HeLa tumor-bearing mice, as well as enhanced the cytotoxic activity of cisplatin both in vitro and in vivo. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | p53 | ||
Structure
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