洛伐他汀
| CAS号 | 75330-75-5 | 货号 | BCP20921 |
| 中文名 | 洛伐他汀 | ||
| 英文名 | Lovastatin | ||
| 中文别名 | |||
| 英文别名 | Mevinolin; Mevacor; Monacolin K; Altoprev; MK 803; MK-803; MK803; Monacolin K; | ||
| 分子式 | C24H36O5 | 分子量 | 404.54 |
| 生物活性 | Lovastatin inhibits HMGCR, blocking the enzyme-catalyzed transformation of 3-hydroxy-3-methylglutaryl CoA into mevalonate. Lovastatin is a statin natural product isolated from numerous sources including the Pleurotus ostreatus oyster mushroom, demonstrating hypocholesterolemic and antiproliferative properties. The biosynthesis of cholesterol requires mevalonate as a building block and elimination of mevalonate generation subsequently interrupts cholesterol synthesis, leading to a reduction of circulating low-density lipoproteins. Lovastatin demonstrates arrest of the cell cycle at the G1 phase in bladder carcinoma T24 cells. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | HMGCR | ||
结构式
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