PF-04880594
| CAS No. | 1111636-35-1 | Cat. No. | BCP21016 |
| Name | PF-04880594 | ||
| Synonyms | PF04880594; PF 04880594; | ||
| Formula | C19H16F2N8 | M. Wt | 394.38 |
| Description | PF-04880594 is a RAF inhibitor, which induces ERK phosphorylation and RAF dimerization in those epithelial tissues that undergo hyperplasia. PF-04880594 stimulates production of the inflammatory cytokine interleukin 8 in HL-60 cells. Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901. The combination treatment with PF-04880594 and MEK inhibitors might greatly increase the safety and therapeutic index of RAF inhibitors for the treatment of melanoma and other cancers. | ||
| Pathways | MAPK Pathway | ||
| Targets | Raf | ||
Structure
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