Enalapril Maleate

  • Chemical Properties
CAS No. 76095-16-4 Cat. No. BCP21378
Name Enalapril Maleate
Synonyms Maleate, Enalapril; MK 421; MK-421; MK421;
Formula C24H32N2O9 M. Wt 492.52
  • Biological Activity
Description Enalapril maleate is an effective and potent angiotensin-converting enzyme inhibitor that is used to treat hypertension and heart failure. The compound has been used to study diabetic angiopathy in diabetic rats and inhibition of ACE in hog plasma. ACE inhibitors disturb the enin-angiotensin- aldosterone system. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
Pathways Protease/Metabolic Enzyme Hormone Pathay 
Targets RAAS/ACE 

Structure

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