Concanamycin A

  • Chemical Properties
CAS No. 80890-47-7 Cat. No. BCP21840
Name Concanamycin A
Synonyms X 4357 B; X-4357 B; X4357 B; NSC 674620;Antibiotic X 4357 B;
Formula C46H75NO14 M. Wt 866.1
  • Biological Activity
Description Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that displays > 2000-fold selectivity over other H+-ATPases (IC50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H+-ATPases and porcine P-type Na+,K+-ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.
Pathways Ion Channel/Membrane Transporter 
Targets Proton Pump 

Structure

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