环杷明
| CAS号 | 4449-51-8 | 货号 | BCP01796 |
| 中文名 | 环杷明 | ||
| 英文名 | Cyclopamine | ||
| 中文别名 | 环巴胺; | ||
| 英文别名 | 11-Deoxojervine; | ||
| 分子式 | C27H41NO2 | 分子量 | 411.62 |
| 生物活性 | Cyclopamine, also known as 11-deoxojervine, is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by inhibiting the hedgehog signaling pathway (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed. Cyclopamine was named for one-eyed lambs which were born to sheep which grazed on wild corn lily at a farm in Idaho. | ||
| 信号通路 | Wnt/Stem Cell | ||
| 靶 点 | Hedgehog | ||
结构式
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