环杷明

参考资料仅供科学研究，不可用于个人用途。

货号：BCP01796CAS号：4449-51-8纯度：98%

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CAS号	4449-51-8	货号	BCP01796
中文名	环杷明
英文名	Cyclopamine
中文别名	环巴胺;
英文别名	11-Deoxojervine;
SMILES	O[C@@H](CC[C@@]12C)CC1=CC[C@@]([H])([C@@]2(CC3=C4C)[H])[C@@]3(CC[C@@]54O[C@]6([H])C[C@@H](CN[C@]6([C@]5C)[H])C)[H]
化学名称
分子式	C27H41NO2	分子量	411.62
纯度	98%	配送	惯例下常温包邮
产品描述	Cyclopamine, also known as 11-deoxojervine, is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by inhibiting the hedgehog signaling pathway (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed. Cyclopamine was named for one-eyed lambs which were born to sheep which grazed on wild corn lily at a farm in Idaho.