NPS 2143
| CAS No. | 284035-33-2 | Cat. No. | BCP02421 |
| Name | NPS 2143 | ||
| Synonyms | NPS-2143;NPS2143;SB-262470;SB 262470;SB262470; | ||
| Formula | C24H25ClN2O2 | M. Wt | 408.92 |
| Description | NPS 2143 blocks increases in cytoplasmic Ca2+ concentrations with IC50 of 43 nM elicited by activating the Ca2+ receptor in HEK 293 cells expressing the human Ca2+ receptor. NPS 2143 stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells with EC50 of 41 nM. Moreover, NPS 214 also blocks the inhibitory effects of calcimimetic NPS R-467 on PTH secretion from bovine parathyroid cells and the inhibitory effects of extracellular Ca2+ on isoproterenol-stimulated increases in cyclic AMP formation. In HEK-293 cells transiently expressing hCaSRs, NPS 2143 significantly suppresses the kokumi taste by effectively inhibiting the activity of both GSH (data not shown) and γ-Glu-Val-Gly. A recent study shows that NPS 2143 treatment suppresses low molecular weight fractions of azuki hydrolysate-induced cholecystokinin (CCK) secretion in CaSR-transfected HEK 293 cells. | ||
| Pathways | GPCR/G Protein | ||
| Targets | CaSR | ||
Structure
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