盐酸甲状旁腺激素
| CAS号 | 364782-34-3 | 货号 | BCP02533 |
| 中文名 | 盐酸甲状旁腺激素 | ||
| 英文名 | Cinacalcet hydrochloride | ||
| 中文别名 | 盐酸西那卡赛;西那卡赛盐酸盐; | ||
| 英文别名 | Cinacalcet HCl;Mimpara;Sensipar;AMG-073;AMG 073;AMG073; | ||
| 分子式 | C22H22F3N.HCl | 分子量 | 393.88 |
| 生物活性 | Cinacalcet Hydrochloride is the orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | CaSR | ||
结构式
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