Abitrexate

CAS No.	59-05-2	Cat. No.	BCP02078
Name	Abitrexate
Synonyms	Methotrexate；Amethopterin; CL14377; WR19039；CL-14377; WR-19039；CL 14377; WR 19039;
Formula	C20H22N8O5	M. Wt	454.44

Description	Methotrexate (0.1-10 mM) induces apoptosis of in vitro activated T cells from human peripheral blood. Methotrexate achieves clonal deletion of activated T cells in mixed lymphocyte reactions. Methotrexate can selectively delete activated peripheral blood T cells by a CD95-independent pathway. Methotrexate is taken up by cells via the reduced folate carrier and then is converted within the cells to polyglutamates. Methotrexate leads to diminished production of leukotriene B4 by neutrophils stimulated ex vivo. Methotrexate polyglutamates inhibit the enzyme aminoimidazolecarboxamidoadenosineribonucleotide (AICAR) transformylase more potently than the other enzymes involved in purine biosynthesis. Methotrexate is also known to suppress TNF activity by suppressing TNF-induced nuclear factor-κB activation in vitro, in part related to a reduction in the degradation and inactivation of an inhibitor of this factor, IκBα, and probably related to the release of adenosine. Methotrexate suppresses
Pathways	Cell Cycle/DNA Damage Others Pathway
Targets	ADC Related DHFR

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