Zofenopril

  • Chemical Properties
CAS No. 81872-10-8 Cat. No. BCP09233
Name Zofenopril
Synonyms Zofenoprilum;SQ 26900;SQ-26900;SQ26900;(4S)-1-[(2S)-3-(Benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)-L-proline;
Formula C22H23NO4S2 M. Wt 429.56
  • Biological Activity
Description Zofenopril is a sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zofenopril is hydrolyzed in vivo into its active form zofenoprilat. Zofenoprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zofenoprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
Pathways Protease/Metabolic Enzyme Hormone Pathay 
Targets RAAS/ACE 

Structure

Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
Service & Tech Support:orders@biochempartner.com
Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.