LDE225二磷酸盐
| CAS号 | 1218778-77-8 | 货号 | BCP11860 |
| 中文名 | LDE225二磷酸盐 | ||
| 英文名 | LDE225 Diphosphate | ||
| 中文别名 | 索尼吉布二磷酸盐; | ||
| 英文别名 | NVP-LDE225; NVP-LDE-225; NVP LDE225;LDE-225;LDE 225;Erismodegib Diphosphate;Sonidegib phosphate; | ||
| 分子式 | C26H32F3N3O11P2 | 分子量 | 681.49 |
| 生物活性 | Sonidegib phosphate, the phosphate of sonidegib, also known as LDE225 or NPV-LDE225. Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) being developed as an anticancer agent by Novartis. It was approved by the FDA for treating basal cell carcinoma in July 2015. It has demonstrated significant efficacy against melanoma in vitro and in vivo. It also demonstrated efficacy in a mouse model of pancreatic cancer. | ||
| 信号通路 | GPCR/G Protein Wnt/Stem Cell | ||
| 靶 点 | Smoothened/Smo Hedgehog | ||
结构式
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