Methylprednisolone sodium succinate

CAS No.	2375-03-3	Cat. No.	BCP11883
Name	Methylprednisolone sodium succinate
Synonyms	6 alpha-Methylprednisolone Sodium Hemisuccinate;6α-Methylprednisolone 21-hemisuccinate sodium salt;
Formula	C26H33NaO8	M. Wt	496.53

Description	Methylprednisolone Sodium Succinate is the sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. Methylprednisolone sodium succinate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production such as IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.
Pathways	GPCR/G Protein
Targets	Glucocorticoid Receptor

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